Regulation
Bile salt production is regulated by the concentration of bile salts circulating within plasma. There is a negative feedback loop upon 2 target enzymes:
- HMG CoA reductase, the enzyme which produces cholesterol within hepatocytes
- 7-alpha-hydroxylase, the enzyme involved in making the precursor or primary bile acids
Consequently, an elevated plasma bile salt concentration decreases primary bile salt production, and vice versa.
Reference
- Chiang JY. Bile acids: regulation of synthesis. J Lipid Res. 2009 Oct;50(10):1955-66
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