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Relative risk of upper GI bleeding (bleed) based on various demographic and pharmacologic risk factors

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Relative Risk of Upper GI bleeding based on various Demographic and Pharmacologic risk factors

Risk Factor

Relative Risk (95% CI)

Male Sex (*)

2.1 (1.9-2.3)

Age 70-80y (*)

4.5 (4.0-4.9)

History of previous bleeding Peptic Ulcer Disease (**)

4.4 (3.6-5.5)

Aspirin (**)

1.8 (1.6-2.0)

Oral anticoagulant (**)

1.8 (1.4-2.3)

High dose corticosteroids (**)

1.9 (1.1-3.4)

low or medium dose NSAIDs (**)

2.0 (1.6-2.6)

Oral anticoagulant plus aspirin (**)

3.6 (2.1-6.3)

Dual antiplatelet therapy (**)

3.7 (2.4-5.8)

High dose NSAIDs (**)

3.9 (3.1-4.9)

Low or medium dose NSAIDs plus aspirin (**)

4.8 (3.5-6.6)

* Aliment Pharmacol Ther. 2013 Apr;37(7):738-48.

** Circulation. 2011 Mar 15;123(10):1108-15


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