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The dry eyes can be treated by diathermy obliteration of the lacrimal punctum and instillation of artificial tears consisting of hydroxyethylcellulose drops.
Meticulous oral hygiene with toothpaste, dental floss and a special 1% chlorhexidine gluconate preparation helps to control the dental caries and periodontal disease.
Artificial saliva may help to keep the mouth moist.
First approach to extra-glandular (systemic) major organ-system disease is oral/parenteral corticosteroids
Various DMARDs (methotrexate, azathioprine) have been successfully employed as steroid-sparing agents although none is specifically approved for Sjogren.
Hydroxychloroquine may be used to treat inflammatory polyarthritis
B cell depletion may have a role in certain severe extra-glandular manifestations (vasculitis)
TNF-alpha inhibitors have not proved effective for Sjogren
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