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Upper GI bleeding (bleed) risk and warfarin (anticoagulant)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Relative Risk of Upper GI bleeding based on various Demographic and Pharmacologic risk factors

Risk Factor

Relative Risk (95% CI)

Male Sex (*)

2.1 (1.9-2.3)

Age 70-80y (*)

4.5 (4.0-4.9)

History of previous bleeding Peptic Ulcer Disease (**)

4.4 (3.6-5.5)

Aspirin (**)

1.8 (1.6-2.0)

Oral anticoagulant (**)

1.8 (1.4-2.3)

High dose corticosteroids (**)

1.9 (1.1-3.4)

low or medium dose NSAIDs (**)

2.0 (1.6-2.6)

Oral anticoagulant plus aspirin (**)

3.6 (2.1-6.3)

Dual antiplatelet therapy (**)

3.7 (2.4-5.8)

High dose NSAIDs (**)

3.9 (3.1-4.9)

Low or medium dose NSAIDs plus aspirin (**)

4.8 (3.5-6.6)

* Aliment Pharmacol Ther. 2013 Apr;37(7):738-48.

** Circulation. 2011 Mar 15;123(10):1108-15


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