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Causes of a low haptoglobin

Authoring team

Classically, a low haptoglobin concentration is indicative of intravascular haemolysis.

There are other causes of a low haptoglobin, these include:

  • extravascular haemolysis - some free haemoglobin leaks from the phagocytic cells of the spleen
  • chronic liver disease
  • metastatic malignancy
  • sepsis

Reference

  1. Anderson C et al. Haptoglobin. Antioxid Redox Signal. 2017 May 10;26(14):814-831

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