This site is intended for healthcare professionals

CPD
CPD
Pro
Pro
Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Interactions

Authoring team

There is a close association between platelets, endothelium and the coagulation cascade:

  • released on activation, platelet factor 3 - PF3 - facilitates factor IXa, so enhancing the intrinsic pathway
  • PF3 facilitates the conversion of prothrombin to thrombin directly
  • small amounts of coagulation factor are found within platelets e.g. V and XI, as well as fibrinogen
  • platelet plasma membranes have receptor sites for factors e.g. V and X, so localising the deposition of fibrin
  • damaged endothelium can trap and activate factors IX, X and V
  • normal endothelium prevents thrombosis by the production of mediators such as prostacyclin GI2, heparin and plasminogen activator

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.