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Types of bisphosphonates

Authoring team

Bisphosphonates include:

  • disodium etidronate:
    • in Paget's disease:
    • in hypercalcaemia of malignant disease:
    • in osteoporosis
  • disodium alendronate
  • risedronate
  • disodium pamidronate
  • sodium clodronate
  • zoledronic acid
  • ibandronate
  • tiludronate

Nitrogen-containing bisphosphonates include alendronate, risedronate, ibandronate, pamidronate, and zoledronic acid. Non-nitrogen-containing bisphosphonates include etidronate, clodronate, and tiludronate.

All bisphosphonates inhibit bone resorption by attaching to hydroxyapatite binding sites on the bone, particularly in areas with active resorption.

Reference

  1. Farrell KB, Karpeisky A, Thamm DH, Zinnen S. Bisphosphonate conjugation for bone specific drug targeting. Bone Rep. 2018 Dec;9:47-60.

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