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  • inhibition of bacterial DNA gyrase (a topoisomerase) - this enzyme is involved in the supercoiling of DNA, and topoisomerase IV

  • DNA gyrase is unique among topoisomerases in its ability to introduce negative supercoils into bacterial DNA - this supercoiling is important for initiation and propagation of DNA synthesis and transcription of mRNA from many genes

This effects results in an impairment of DNA replication and protein synthesis.

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