Ovarian cancer (risk of malignancy index (RMI))

Risk of malignancy index (RMI)

RMI I is a product of the ultrasound scan score (U), menopausal status (M) and serum CA125 level.

RMI I = U x M x CA125

• The ultrasound result is scored 1 point for each of the following characteristics:
  • multilocular cysts, solid areas, metastases, ascites, bilateral lesions
    • U = 0 for an ultrasound score of 0 points,
    • U = 1 for an ultrasound score of 1 point,
    • U = 3 for an ultrasound score of 2-5 points
      
      
• Menopausal status is scored as 1 = pre-menopausal and 3 = post-menopausal. The classification of 'post-menopausal' is a woman who has had no period for more than 1 year or a woman over 50 who has had a hysterectomy
  
  
• Serum CA125 is measured in IU/ml

If RMI >= 250 then must be referred to a specialist multidisciplinary team

Reference:

• 1) NICE (April 2011). Ovarian cancer