Diagnosis of premature ovarian insufficiency

Diagnosing premature ovarian insufficiency

• take into account the woman's clinical history (for example, previous medical or surgical treatment) and family history when diagnosing premature ovarian insufficiency
  
  
• diagnose premature ovarian insufficiency in women aged under 40 years based on:
  • menopausal symptoms, including no or infrequent periods (taking into account whether the woman has a uterus) and
  • elevated FSH levels on 2 blood samples taken 4-6 weeks apart
    
    
• do not diagnose premature ovarian insufficiency on the basis of a single blood test
• do not routinely use anti-Müllerian hormone testing to diagnose premature ovarian insufficiency (2)

If there is doubt about the diagnosis of premature ovarian insufficiency, refer the woman to a specialist with expertise in menopause or reproductive medicine

Reference:

1. Menopause: diagnosis and management. NICE Guideline (November 2015 - last updated December 2019)
2. Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update. 2014 May-Jun;20(3):370-85.