This site is intended for healthcare professionals

CPD
CPD
Pro
Pro
Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Chromosomal abnormalities

Authoring team

Studies reveal a high incidence of non-random chromosomal abnormalities in 70% of cases of ALL and 50% of cases of AML. The genes involved are intimately concerned with the regulation of cell growth.

  • t(9;22), C-ALL; L1 or L2 - more common in adults poor prognosis
  • t(4;11), Null-ALL; L2 - infants; more in girls, high blast count, poor prognosis
  • t(8;14), B-ALL; L3 - hepatosplenomegaly; conventional treatment gives poor prognosis; better with lymphoma type treatment
  • t(8;21), AML-M2 - young; mean age 28 yrs, abnormal eosinophils, solid leukaemic tumours, 75-85% remission when treated
  • t(15;17), AML-M3 - abnormal promyelocytes, 50% develop DIC, durable remissions
  • inv/del/t(16), AML-M4 - 5% of AML abnormal eosinophils 70-90% remission after treatment

Note - t(9;22) is the Philadelphia chromosome.

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.