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Classification of non Hodgkin's lymphoma (NHL)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

classification

Several different classification systems have been brought forward over the past few years but none have gained universal acceptance.

  • historically NHL was classified according to the International Working Formulation (IWF) as either low, intermediate or high grade based on the morphology and natural history (1).
  • currently the Revised European American Lymphoma (REAL)/WHOclassification is in use

REAL/WHOclassification

B-cell neoplasms

  1. Precursor B-cell neoplasm: precursor B-acute lymphoblastic leukemia/lymphoblastic lymphoma (LBL).
  2. Peripheral B-cell neoplasms
  • B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma.
  • B-cell prolymphocytic leukemia.
  • Lymphoplasmacytic lymphoma/immunocytoma.
  • Mantle cell lymphoma.
  • Follicular lymphoma.
  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type.
  • Nodal marginal zone B-cell lymphoma (± monocytoid B-cells).
  • Splenic marginal zone lymphoma (± villous lymphocytes).
  • Hairy cell leukemia.
  • Plasmacytoma/plasma cell myeloma.
  • Diffuse large B-cell lymphoma.
  • Burkitt lymphoma.

T-cell and putative NK-cell neoplasms

  1. Precursor T-cell neoplasm: precursor T-acute lymphoblastic leukemia/LBL.
  2. Peripheral T-cell and NK-cell neoplasms.
  • T-cell chronic lymphocytic leukemia/prolymphocytic leukemia.
  • T-cell granular lymphocytic leukemia.
  • Mycosis fungoides/Sézary syndrome.
  • Peripheral T-cell lymphoma, not otherwise characterized.
  • Hepatosplenic gamma/delta T-cell lymphoma.
  • Subcutaneous panniculitis-like T-cell lymphoma.
  • Angioimmunoblastic T-cell lymphoma.
  • Extranodal T-/NK-cell lymphoma, nasal type.
  • Enteropathy-type intestinal T-cell lymphoma.
  • Adult T-cell lymphoma/leukemia (human T-lymphotrophic virus [HTLV] 1+).
  • Anaplastic large cell lymphoma, primary systemic type.
  • Anaplastic large cell lymphoma, primary cutaneous type.
  • Aggressive NK-cell leukemia.

Reference:

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