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Aetiology

Authoring team

Cryoglobulin is normally present in healthy individuals at low levels. The prime risk factor for cryoglobulinemia is drug use, as 90% of cases of cryoglobulinemic vasculitis are associated with HCV infections. (1,2). Others include:

  • idiopathic / essential mixed cryoglobulinaemia
  • lymphoproliferative disease
  • autoimmune disease
  • infections

Reference

  1. Roccatello D, Saadoun D, Ramos-Casals M, et al. Cryoglobulinaemia. Nat Rev Dis Primers. 2018 Aug 2;4(1):11.
  2. Sansonno D, Dammacco F. Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations. Lancet Infect Dis. 2005 Apr;5(4):227-36.

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