This site is intended for healthcare professionals

CPD
CPD
Pro
Pro
account_circleSign in
Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Inhibitor syndrome

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The presence of circulating inhibitors of blood coagulation is indicated by:

  • an increased partial thromboplastin time which cannot be corrected by addition of normal plasma; formally tested as a 30 minute 1:1 mix test - incubation of patient plasma plus an equal volume of normal plasma
  • normal or increased prothrombin time

Increased PTT and PT occurs only when specific coagulation factors fall to below 30% of their normal values.

Two types of circulating inhibitor are recognised:

  • antibodies directed against specific coagulation proteins
  • inhibitors directed against phospholipid function - principally, lupus anticoagulant

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.