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Protamine sulphate

Authoring team

This drug neutralizes the effects of heparin. It is most commonly used to neutralize heparin-induced anticoagulation after separation from cardiopulmonary bypass. When appropriately dosed, this neutralization reduces the risk of postoperative bleeding.

Reference

  1. Holzmacher JL, Sarani B. Indications and Methods of Anticoagulation Reversal. Surg Clin North Am. 2017 Dec;97(6):1291-1305

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