Tranexamic acid
Tranexamin acid is used in situations where excessive haemorrhage cannot be controlled e.g.:
- post-operatively e.g prostatectomy, bladder surgery
- menorrhagia associated with IUCD's
- haemophiliac dental extraction
- epistaxis
- reduce the effect of fibrinolytic drugs
- as a second-line agent in hereditary haemorrhagic telangiectasia
It competitively inhibits the conversion of plasminogen to plasmin.
Cautions / contra-indications:
- massive haematuria from upper renal tract as may cause ureteric thrombotic obstruction
- history of thromboembolic disease
- pregnancy
It interacts with the oral contraceptive pill to increase the risk of thrombosis.
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