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Clinical features

Authoring team

The clinical picture varies widely according to the degree of tumour cell infiltration and the effects of IgM.

Commonly encountered features may include:

  • peak incidence at age 60 - 70 years; slight preponderance for males
  • usually present with fatigue related to anaemia
  • serum hyperviscosity - causing mucosal and gastrointestinal bleeding, and retinal haemorrhage; due to engorged vessels and platelet dysfunction
  • purpura
  • hepatosplenomegaly and lymphadenopathy (rare in multiple myeloma)
  • bone involvement is rare
  • neurologic symptoms - alterations in consciousness, peripheral neuropathy, visual disturbance
  • nausea and vertigo

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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