Clostridioides difficile (previously known as Clostridium difficile) is a species of the genus Clostridia. Some pathogenic forms are associated with the development of pseudomembranous colitis, usually after antibiotic therapy.
- in the UK, since January 2021 there has been an increase in Clostridioides difficile infections (CDI) for which there is no clear explanation
- the UKHSA is investigating a newly evolving ribotype (955) which has emerged in England over the last 2 years (total 50 cases)
- this ribotype may present with severe disease or as a recurrence and has caused significant mortality
- microbiological sensitivity testing has identified that the ribotype 955 isolates are RESISTANT to treatment metronidazole and therefore the use of this agent will be ineffective for treating CDI
- UK Health Security Agency (18/1/24). Emergence of new Clostridioides difficile ribotype – 955 - update