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Aetiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

60-90% of the genital and enteric forms of the disease are associated with HLA B27. The risks for developing Reiter's disease are:

  • 2% in patients attending clinics for non-gonococcal urethritis
  • 0.2% in all patients following bacillary dysentery
  • 20% in HLA B27 patients following bacillary dysentery
  • age 16 to 35
  • male to female ratio is 20:1
  • the genital form is rare in children but the enteric form does occur

Reiter's syndrome is the result of a genetically determined pathological immune response to an infectious agent.

The agents implicated are:

  • genital - chlamydia, gonorrhoea
  • enteric - salmonella, yersinia, shigella, campylobacter

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