Catastrophic antiphospholipid syndrome
Catastrophic antiphospholipid syndrome (CAPS) is a rare life-threatening cause of multi-organ failure with an acute onset (1).
- observed in less than 1% of APS patients (2)
- it is characterized by the development of microthrombi in multiple small vascular beds in several organ systems leading to multioragn failure e.g. - typically the brain, kidneys, lung and the skin
Important differential diagnosis include -thrombotic thrombocytopaenic purpura, haemolytic uraemic syndrome, and disseminated intravascular coagulation (2)
Combinations of treatment are typically used including anticoagulation with heparin/warfarin. In addition Immunomodulatory therapies including plasmaphaeresis, intravenous human IgG, corticosteroids and rituximab have been employed (1).
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