Baclofen in the treatment of spasticity
- baclofen is a gamma-aminobutyric acid (GABA) analogue - it reduces the release of excitatory transmitters in the spinal cord via the inhibition of firing of alpha- and gamma-motor neurones
- there is evidence that baclofen reduces the severity and frequency of clonus and spasticity (1)
- side effects include confusion, hypotonia, muscle weakness, fatigue and drowsiness. Abrupt withdrawal of this drug can result in visual hallucinations, cardiac arrhythmias and convulsions
Reference:
- (1) Kita M, Goodkin DE (2000). Drugs used to treat spasticity. Drugs, 59, 487-95.
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