Clinical features
LGMD is a clinically heterogeneous disease, from a mild late onset form to severe and even congenital forms.
LGMD is characterised by:
- progressive symmetrical atrophy and weakness of the musccles of:
- proximal limbs
- shoulder and pelvic girdles
- trunk muscles
- the facial muscles are spared
Onset of symptoms is usually during the first two decades of life. Patients are usually confined to a wheelchair within 10-20 yr.
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