This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Solriamfetol for treating excessive daytime sleepiness caused by narcolepsy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Solriamfetol (SUNOSI, formerly JZP-110 and ADX-N05) is an FDA-approved dopamine and norepinephrine reuptake inhibitor indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or OSA (obstructive sleep anpoea)

  • solriamfetol has lower binding affinity to dopamine and norepinephrine transporters than traditional stimulants, and lacks the monoamine-releasing effects of amphetamines at therapeutic doses
  • solriamfetol significantly increased wakefulness and reduced sleepiness in participants with obstructive sleep apnea and excessive sleepiness; most adverse events were mild or moderate in severity (1)

NICE state that:

  • Solriamfetol is recommended as an option for treating excessive daytime sleepiness in adults with narcolepsy with or without cataplexy. This is only if modafinil and either dexamfetamine or methylphenidate have not worked well enough or are not suitable

Notes:

  • NICE note that excessive daytime sleepiness caused by narcolepsy is usually first treated with modafinil, then dexamfetamine or methylphenidate. Availability of other treatments such as sodium oxybate and pitolisant varies in clinics across England. If available, they're normally used after modafinil and dexamfetamine or methylphenidate
    • clinical trial evidence shows that solriamfetol reduces excessive daytime sleepiness compared with placebo
    • does not show a difference in quality of life but this is not certain because of the way that quality of life was assessed in the trial
    • is no data comparing solriamfetol with dexamfetamine or methylphenidate
    • is no direct data comparing it with sodium oxybate or pitolisant

Reference:


Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.