Diagnostic criteria for sporadic CJD
The diagnostic criteria for (classical) sporadic Creutzfeldt-Jacob disease are:
- definite diagnosis, any of the following:
- neuropathologically confirmed
- positive PrP Western blot
- presence of scrapie-associated fibrils
- probable diagnosis:
- progressive dementia
- typical EEG
- two or more of:
- myoclonus
- visual or cerebellar signs
- pyramidal/extrapyramidal signs
- akinetic mutism
- possible diagnosis:
- progressive dementia
- two of:
- myoclonus
- visual or cerebellar signs
- pyramidal/extrapyramidal signs
- akinetic mutism
- duration <2 years
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