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Investigations

Authoring team

The investigation of Whipple's disease demonstrates:

  • rheumatoid factor negative
  • small intestinal biopsy reveals:
    • minimal villous atrophy
    • PAS positive staining foamy macrophages with intracellular bacilli

It has been shown recently that a definitive diagnosis may be made using PCR amplification and sequencing of unique sequences of 16s rRNA. This approach permits diagnosis from a sample of peripheral blood.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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