phentermine is a centrally acting catecholamine which was previously licensed in the UK as a short-term adjunct to conservative therapy in obese patient.
The Medicines Control Agency withdrew Phentermine from the UK market in April 2000. This was because of concerns that anoretic drugs such as phentermine are linked to pulmonary hypertension and valvular disorders
Reference:
Bagchi D, Preuss HG (2012). Obesity: Epidemiology, Pathophysiology, and Prevention. (Second ed.). CRC Press. p. 314. ISBN 9781439854259.
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