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Familial Creutzfeldt-Jacob disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The familial forms of Creutzfeldt-Jacob (CJD) disease:

  • have a wide spectrum of clinical features
  • may vary in its clinical features between and within families
  • have an autosomal dominant mode of inheritence
  • account for 10% of cases of CJD

In general:

  • familial CJD presents earlier, from 40 years on
  • the clinical course is longer

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