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Aetiology

Authoring team

The common aetiological factor in all forms of osteopetrosis is a defect in osteoclast activity. Invariably there is reduced bone resorption; occasionally excess bone deposition is also present.

Histologically the osteoclasts are numerous and exceptionally large.

Reference

  1. Del Fattore A, Cappariello A, Teti A; Genetics, pathogenesis and complications of osteopetrosis. Bone. 2008 Jan;42(1):19-29.

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