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Caudal regression sequence

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The caudal regression sequence describes a particular pattern of malformation which is frequently associated with maternal diabetes in pregnancy.

The sequence includes, to a variable degree:

  • incomplete development of the sacrum and lumbar vertebrae; the extreme being sacral agenesis
  • femoral hypoplasia - reduced growth of the caudal region
  • neural tube defects, with disruption of the spinal cord distally

Clinically any of the sequelae of these may be noted, in addition to which a frequent feature is flattened buttocks.

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