Adrenaline in adults with anaphylaxis

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Use of adrenaline in anaphylactic shock

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Doses of emergency drugs for anaphylaxis and angio-oedema (1,2):

the majority of anaphylaxis episodes occurring in a community setting will respond to initial treatment with IM adrenaline, although currently around 10% receive more than one dose (2)

this may sometimes be due to the use of auto-injectors which cannot deliver an age/weight-appropriate dose in most patients

less than 1% of reactions are refractory to initial adrenaline treatment, and intensive care admissions for anaphylaxis are uncommon

 CKS (2021). Angio-oedema and anaphylaxis.

Emergency treatment of anaphylactic reactions. Guidelines for healthcare providers. Working Group of the Resuscitation Council (UK).2021

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Drugs	Adult or child older than 12 years	Child aged 6-12 years	Child aged 6 months - 6 years	Child aged under 6 months
Adrenaline (IM*) 1:1000 (repeat after 5 minutes if no better)	500 micrograms (0.5 mL) (give 300 micrograms IM [0.3 mL] in a child who is small or prepubertal)	300 micrograms (0.3 mL)	150 micrograms (0.15 mL)	100-150 micrograms (0.1 to 0.15 mL)

Adrenaline in adults with anaphylaxis

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