This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Cyclo-oxygenase pathway

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Once arachidonic acid has been liberated cyclo-oxygenase catalyzes a step common to most body cells:

  • arachidonic acid is converted to the cyclic endoperoxidase, PGG2, via an intermediate radical
  • PGG2 is then converted to PGH2

The next prostanoid produced from PGH2 is largely dependent on the enzymes produced by the individual cell. For example:

  • platelets have the enzyme thromboxane synthetase which can produce thromboxane A2 - TXA2
  • vascular endothelium has the enzyme prostacyclin synthetase for the production of prostaglandin I2 - PGI2
  • many cells have enzymes capable of producing prostaglandins D2, E2 and F2alpha: PD2, PE2, PF2alpha

Generally, the prostanoids have a short half-life. Most are rapidly taken up and degraded by intracellular enzymes. PGI2 is degraded by the kidney, also the route by which most prostanoid metabolites are excreted.

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.