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Once arachidonic acid has been liberated cyclo-oxygenase catalyzes a step common to most body cells:
The next prostanoid produced from PGH2 is largely dependent on the enzymes produced by the individual cell. For example:
Generally, the prostanoids have a short half-life. Most are rapidly taken up and degraded by intracellular enzymes. PGI2 is degraded by the kidney, also the route by which most prostanoid metabolites are excreted.