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Predisposing factors

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Factors predisposing to local recurrence after breast cancer surgery include:

  • positive axillary nodes at time of surgery:
    • it has been suggested that all patients with positive nodes at the time of initial surgery should have radiotherapy to the breast
    • this has no major benefit:
      • after breast conservation, local recurrence may be reduced but prognosis remains the same
      • after mastectomy, prognosis is actually worsened by local radiotherapy
  • large initial tumour size
  • multifocal tumour
  • histological features:
    • positive margins within the resected specimen
    • lymphatic and vascular invasion
    • aggressive tumour

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