Switching antidepressant (mirtazapine to monoamine oxidase inhibitors (MAOIs)) in adults
Mirtazapine to monoamine oxidase inhibitors (MAOIs)
- switching to an MAOI is always a complex switch and you should follow specialist advice.
Taper, washout and switch with specialist advice
- gradually reduce the dose of mirtazapine and stop; wait 7 to 14 days before starting the MAOI
- specialist will advise the duration of the washout period on a case-by-case basis taking into consideration the MAOI being started
- specialist will advise the duration of the washout period on a case-by-case basis taking into consideration the MAOI being started
- cross-tapering is not recommended due to the high risk of serotonin syndrome.
Reference:
- NHS Specialist Pharmacy Service (February 2023).Mirtazapine to other antidepressants: switching in adults
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