Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to agomelatine in adults
SNRIs to agomelatine
Cross-taper
- cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability
- is limited experience with this switch so extra caution is required. Although interactions are not expected, agomelatine is not expected to mitigate discontinuation reactions from stopping the SNRI
Reference:
- NHS Specialist Pharmacy Service (February 2023). SNRIs to other antidepressants: switching in adults
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