Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to vortioxetine in adults
SNRIs to vortioxetine
- is limited experience with this switch so extra caution is required to avoid serotonin syndrome.
Direct switch
- a direct switch, i.e. stopping one medicine and then starting the new medicine the following day, is normally possible.
Taper, washout and switch
- alternatively, gradually reduce the dose of the SNRI and stop; wait for a period before starting vortioxetine. Clinicians should decide the duration of the washout period on a case-by-case basis.
Reference:
- NHS Specialist Pharmacy Service (February 2023). SNRIs to other antidepressants: switching in adults
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