Last reviewed dd mmm yyyy. Last edited dd mmm yyyy
Switching antidepressant (tricyclic antidepressants (TCA) to moclobemide)
Taper, washout and switch
From TCAs other than clomipramine
After stopping the TCA, wait 7 days before starting moclobemide.
From clomipramine
After stopping clomipramine, wait 7 to 21 days before starting moclobemide. The manufacturer for clomipramine suggests a washout period of 21 days whereas other sources suggest shorter periods. Clinicians should decide the duration of the washout period on a case-by-case basis.
Reference:
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