423 hospitalised patients with refractory schizophrenia were randomised to clozapine or standard treatment with haloperidol.
57% of clozapine patients and 61% of haloperidol patients continued with the assigned drug for the whole year.
Clozapine patients had 5.4% lower symptom scores (score 79.1 vs. 83.6, P=0.02).
Clozapine patients needed fewer days of inpatient treatment (143.8 vs. 168.1, P=0.03).
Despite a higher drug bill in the clozapine group the annual total cost was less because of the fewer inpatient days.
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