Factors associated with increased risk of recurrent venous thromboembolism (VTE) despite adequate anticoagulation

reasons for recurrent VTE despite anticoagulation

The following conditions are associated with an increased risk for recurrent thromboembolism despite anticoagulation:

• anatomic compression (i.e. May-Thurner syndrome, Thoracic Outlet syndrome, etc.)
  
  
• antiphospholipid syndrome
  
  
• cancer
  
  
• dysfibrinogenemia
  
  
• heparin-induced thrombocytopenia
  
  
• myeloproliferative Neoplasm-uncontrolled (e.g. Polycythemia Vera, Essential Thrombocythemia)
  
  
• paroxysmal Nocturnal Hemoglobinuria
  
  
• subtherapeutic anticoagulation (1)

Reference:

• (1) Streiff MB et al. Guidance for the treatment of deep vein thrombosis and pulmonary embolism. J Thromb Thrombolysis. 2016;41(1):32-67.