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Disodium etidronate in Paget's disease

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Disodium etidronate was the first bisphosphonate to be used clinically in the management of Paget's disease.

Adverse effects include:

  • nausea
  • diarrhoea
  • in 5% of patients there may be an increase in bone pain during the first four weeks or so of treatment
  • at higher doses there is an increased incidence of spontaneous fractures because of demineralization that occurs with high doses

There have now been developed second- and third- generation bisphosphonates.

The summary of product characteristics should be consulted before prescribing this drug.

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