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Methotrexate and metronidazole

Authoring team

No interactions between metronidazole and methotrexate are expected.

Suggested management options (1):

  • although there is no drug interaction, in the presence of a severe acute or chronic infection, some people on stable methotrexate therapy may miss doses of methotrexate whilst taking the course of metronidazole
    • restart methotrexate once they feel better

Reference:

  1. NHS Specialist Pharmacy Service (June 30th 2025). Managing interactions with methotrexate

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