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Skin sclerosis (possible causes)

Authoring team

Differential diagnosis of skin sclerosis

  • localised scleroderma

  • systemic sclerosis

  • Infiltrative disorders
    • amyloidosis
    • scleromyxoedema
    • scleroderma of Buschke
    • nephrogenic systemic fibrosis

  • Inflammatory disorders
    • overlap connective tissue diseases (mixed connective tissue disease)
    • eosinophilic fasciitis
    • chronic graft versus host disease
    • lichen sclerosus et atrophicus
    • sarcoidosis
    • carcinoid syndrome
    • silicosis

  • Metabolic disorders
    • myxoedema
    • porphyria cutanea tarda
    • congenital porphyrias
    • acromegaly

  • chemically induced eg bleomycin, vinyl chloride, pentazocine

  • toxic oil syndrome

  • repetitive manual work (skin on hands)

Reference:

  • 1) Arthritis Research Campaign (2010). Topical Reviews - Systemic sclerosis and related disorders.

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