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Drug acetylation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Many drugs require acetylation for their metabolism. In the population there is a bimodal distribution in the rate of acetylation; the fast acetylation is autosomal dominant, and the slow is autosomal recessive.

Drugs which are significantly metabolised by acetylation include:

  • isoniazid
  • hydralazine
  • procainamide
  • phenelzine
  • dapsone
  • some sulphonamides

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