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LDH in testicular cancer

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  • LDH - lactate dehydrogenase - is an enzyme consisting of five isoforms (each with four subunits) that is expressed in cardiac and skeletal muscle as well as in other organs.
  • The highest concentrations of LDH in normal tissue are found in muscle (including skeletal, cardiac and smooth muscle), liver and brain.
  • LDH is expressed on chromosome 12p, which is often amplified in testis cancer cells.
  • LDH is less specific for testicular cancer than HCG or AFP. However, elevated LDH levels are correlated to high tumour burden in seminoma and recurrence in non-seminomatous germ cell tumours.
  • The normal range is <250 U/L (varies slightly by assay)

Reference:

  1. Stephenson A et al. Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline. J Urol. 2019 Aug;202(2):272-281
  2. Baird DC, Meyers GJ, Hu JS. Testicular Cancer: Diagnosis and Treatment. Am Fam Physician. 2018 Feb 15;97(4):261-268

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