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Monoamine oxidase inhibitors (anaesthesia management)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

MAOI's have two salient interactions which makes their use dangerous in general anaesthesia:

  • exaggerated response to exogenous catecholamines
  • inhibition of metabolism of pethidine; respiratory depression, hypotension or hypertension may result

Hence, all MAOI's (type A and B) should be stopped at least three weeks before surgery.

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