bupropion is associated with a dose-related risk of seizure; there is an estimated incidence of about 0.1% (1/1,000) based on doses up to the maximum recommended daily dose of 300 mg per day
in February 2001, the Committee on Safety of Medicines reported 74 reports in the UK seizures suspected as being associated with the use of buproprion. In approximately half of the reports, individuals had either a past history of seizure or risk for their occurrence (1)
Reference:
(1) Committee on Safety of Medicines (2001), Current Problems in Pharmacovigilance, 27, 1-8.
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