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These antibiotics are active against Gram positive cocci and against many anaerobes (including Bacteroides). They have however only a few specific indications because of their serious side-effects.
Clindamycin has largely replaced lincomycin because it is better absorbed and more active.
Lincosamides act by interfering with the process of peptide elongation in bacterial protein synthesis, with a similar binding site to erythromycin.