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Clindamycin and lincomycin

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

These antibiotics are active against Gram positive cocci and against many anaerobes (including Bacteroides). They have however only a few specific indications because of their serious side-effects.

Clindamycin has largely replaced lincomycin because it is better absorbed and more active.

Lincosamides act by interfering with the process of peptide elongation in bacterial protein synthesis, with a similar binding site to erythromycin.

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