ACE inhibitors and hyponatraemia
- angiotensin converting enzyme (ACE) inhibitors have been associated with dilutional hyponatremia (1):
- ACE inhibitors alone can precipitate hyponatremia without co-administration of thiazide diuretics
- hyponatremia induced by ACE inhibitors appears to be dilutional and is accompanied by features of SIADH
- discontinuing the ACE inhibitor leads to resolution of the hyponatremia.
- ACE inhibitors alone can precipitate hyponatremia without co-administration of thiazide diuretics
Reference:
- Falhammar H et al. Associations Between Antihypertensive Medications and Severe Hyponatremia: A Swedish Population–Based Case–Control Study. J Clin Endocrinol Metab. 2020 Apr 14;105(10)
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