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Class I drugs in atrial fibrillation

Authoring team

Class I drugs may be used:

  • for the treatment of atrial fibrillation
  • to maintain sinus rhythm following electrical cardioversion

There are significant complications to the use of type I drugs in atrial fibrillation:

  • prolongation of the QT interval and Torsade des pointes
  • acceleration of the ventricular response if the rhythm is atrial flutter rather than fibrillation
  • increased mortality e.g. quinidine after electrical cardioversion

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