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Diuretic resistance

Authoring team

Diuretic resistance (DR) is defined as a failure to achieve therapeutically desired congestion relief despite using an appropriate diuretic dose

In heart failure patients, the prevalence of diuretic resistance (DR) is estimated as 20%-30% (1)

  • causes of diuretic resistance include poor adherence to drug therapy or dietary sodium restriction, pharmacokinetic issues, and compensatory increases in sodium reabsorption in nephron sites that are not blocked by the diuretic

Reference:

  1. Shams E, Bonnice S, Mayrovitz H N (January 18, 2022) Diuretic Resistance Associated With Heart Failure. Cureus 14(1): e21369. doi:10.7759/cureus.21369
  2. Hoorn EJ, Ellison DH. Diuretic Resistance. Am J Kidney Dis. 2017 Jan;69(1):136-142. doi: 10.1053/j.ajkd.2016.08.027. Epub 2016 Nov 1. PMID: 27814935; PMCID: PMC5182087.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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