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  • flecainide use increases digoxin concentration by about 20%

  • amiodarone causes a significant increase in plasma concentrations of flecainide

  • propranolol co-administration leads to a significant increase in plasma concentrations of both drugs

  • the use of negatively inotropic drugs with flecainide (e.g. verapamil, propranolol, disopyramide) increases the risk of heart failure (1)

  • cimetidine and fluoxetine may also increase flecainide concentrations

  • drugs which can prolong the QT interval (e.g. terfenadine, astemizole, quinine) when used with flecainide further increase the risk of serious ventricular arrhythmias

Reference:

  • Prescribers' Journal (1999), 39 (4), 222-26.

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